| Monday, August 16, 2021 to Monday, August 16, 2021 |
| 1st day of Girls Swim/Dive Practice | All Day | | |
| Friday, August 27, 2021 to Friday, August 27, 2021 |
| Girls Swimming @ Laramie Relays | All Day | | Results:  |
| Saturday, August 28, 2021 to Saturday, August 28, 2021 |
| Girls Swimming @ Laramie Pentathalon | All Day | | Results: |
| Saturday, September 4, 2021 |
| Girls Swimming vs Buffalo | 10:00 am | | |
| Friday, September 10, 2021 to Friday, September 10, 2021 |
| Girls Swimming @ 4A Duals | All Day | Laramie HS | Evanston, Laramie, and Jackson |
| Saturday, September 11, 2021 to Saturday, September 11, 2021 |
| Girls Swimming Duals | All Day | Cheyenne South | South, Rock Springs, and Jackson |
| Friday, September 17, 2021 |
| Girls Swimming @ Gillette | 4:00 pm | | Thunder, Campbell, and Buffalo |
| Saturday, September 18, 2021 |
| Girls Swimming vs KW | 10:00 am | | |
| Friday, September 24, 2021 |
| Girls Swimming-Sheridan Pre-Invite | 4:00 pm | | Natrona |
| Saturday, September 25, 2021 |
| Girls Swimming-Sheridan Invite | 9:00 am | | Natrona, KW, Jackson, East, Laramie, Central |
| Friday, October 1, 2021 |
| Girls Swimming vs Campbell & Thunder | 4:00 pm | | |
| Saturday, October 2, 2021 |
| Girls Swimming @ Kelly Walsh | 10:00 am | | NC, KW, Thunder |
| Saturday, October 9, 2021 |
| Girls Swimming vs KW | 10:00 am | | |
| Friday, October 15, 2021 to Friday, October 15, 2021 |
| Girls Swimming @ Gillette Invite | All Day | | |
| Saturday, October 16, 2021 to Saturday, October 16, 2021 |
| Girls Swimming @ Gillette Invite | All Day | | |
| Friday, October 22, 2021 to Saturday, October 23, 2021 |
| Girl Swimming @ Conference Meet | All Day | Cheyenne South | |
| Friday, November 5, 2021 to Saturday, November 6, 2021 |
| Girls Swimming @ State Meet | All Day | Gillette | |
